Britain's defending Olympic champion Andy Murray pulled out of the Tokyo 2020 men's singles tournament on Sunday ahead of his first-round match.
The 34-year-old, who had been due to play Canada's Felix Auger-Aliassime, was sidelined by a thigh strain.
Murray has been replaced in the draw by Australian Max Purcell.
The Scot will continue to compete in the men's doubles tournament with Joe Salisbury, Team GB said, the pair having won their opening match on Saturday.
"I am really disappointed at having to withdraw but the medical staff have advised me against playing in both events," a statement from Murray read.
"I have made the difficult decision to withdraw from the singles and focus on playing doubles with Joe."
Murray won Olympic gold on Wimbledon's Centre Court at the London 2012 Games, and defended his title in Rio.
He underwent hip surgery in 2018 and 2019, and missed the Australian Open at the start of this year after contracting COVID-19.
Carlos Alcaraz will miss the Madrid Open for the second consecutive year after withdrawing on Friday with a wrist injury, dealing another blow to the world number two's clay court preparations ahead of his French Open title defence.
Novak Djokovic is still working through the injury problems that forced him to miss recent tournaments in Miami and Monte Carlo and said on Friday that he will not feature at next week's Madrid Open, one of the last stops before the French Open.
Mumbai Indians head coach Mahela Jayawardene has defended Jasprit Bumrah after the struggling pace spearhead went a fifth Indian Premier League match without a wicket in Thursday's seven-wicket defeat by Punjab Kings.
Iranian women's football players Fatemeh Pasandideh and Atefeh Ramezanisadeh thanked the Australian government on Friday for offering a "safe haven" and said they wished to resume their sporting careers after rebuilding their lives.
Ollie Watkins still has hope of making England's World Cup squad despite being dropped for last month's friendlies against Uruguay and Japan, with the Aston Villa forward saying all he can do in the last few weeks of the season is score goals.
Dubai Police, in collaboration with the UAE Ministry of Interior, have arrested an Irish fugitive accused of involvement in an organised criminal group linked to international crimes in his home country.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has met with His Highness Sheikh Hamad bin Mohammed Al Sharqi, Supreme Council Member and Ruler of Fujairah, to discuss national priorities and the country’s continued development.