Arsenal and Chelsea made it through to the Europa League last-eight while Inter and Sevilla were knocked out.
Arsenal are into the quarter-finals of the Europa League after beating Rennes 3-0 at the Emirates Stadium.
Pierre-Emerick Aubameyang scored twice and set-up Ainsley Maitland-Niles as the Gunners overturned a two-goal deficit from the first leg, progressing 4-3 overall.
They're joined in the last-eight by London rivals Chelsea, who thrashed Dynamo Kiev 5-0 away from home to complete an 8-0 aggregate victory.
Olivier Giroud claimed a hat-trick, with Marcus Alonso and Callum Hudson-Odoi also getting on the scoresheet.
Italian giants Internazionale were knocked out by Eintracht Frankfurt as Luka Jovic got the only goal of the tie for the German outfit at the San Siro.
That wasn't the only shock result however, as Spanish side Sevilla, who have won the competition a record five times, lost 4-3 to Slavia Prague after extra-time to go out 6-5 on aggregate.
Elsewhere, Villarreal beat Zenit St Petersburg 2-1 to complete a 5-2 aggregate win, Benfica overturned a 1-0 deficit from the first leg to beat Dinamo Zagreb 3-1 overall and Valencia secured a 1-1 draw at Krasnador to progress 3-2.
Sherfane Rutherford struck an unbeaten half-century and Gudakesh Motie produced a brilliant display of spin bowling as West Indies thumped England by 30 runs in a Twenty20 World Cup Group C encounter on Wednesday.
Australia launched their Twenty20 World Cup campaign with a commanding 67-run victory over Ireland in Colombo on Wednesday, powered by four-wicket hauls from Nathan Ellis and Adam Zampa.
Tottenham Hotspur have sacked manager Thomas Frank after eight months in charge, the Premier League club said on Wednesday, after a woeful run of results left the north London club hovering five points above the relegation zone.
South Africa survived Kagiso Rabada's final-over meltdown against Afghanistan and then a double Super Over drama before prevailing in a heart-stopping Group D match of the Twenty20 World Cup on Wednesday.
Pakistan opener Sahibzada Farhan has hit a swift half-century as the 2009 champions comfortably beat the US by 32 runs on Tuesday, clinching their second straight Group A win in the Twenty20 World Cup.
The UAE's Federal Authority for Government Human Resources has announced the official working hours for federal entities during the holy month of Ramadan.
His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President and Prime Minister of the UAE and Ruler of Dubai, attended the final day of the seventh UAE SWAT Challenge at the Al Ruwayyah training ground in Dubai.
The UAE has chaired an emergency meeting of the Arab League in Cairo to address recent Israeli decisions to expand settlements in the Palestinian territories.