England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.

Pegula wins thriller at WTA Finals, Gauff eliminated
Norway says Russian, Belarusian athletes barred from competitions it hosts
Roberto Carlos, Fernando Hierro join Fursan Hispania FC as shareholders
Italy seal dominant win over France as Kane sets England appearance record
Luiten leads the way at DP World Tour Championship
