According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Coventry promoted to Premier League after 25-year absence
Coventry City ended their 25-year absence from the Premier League with a 1-1 draw at Blackburn Rovers, securing promotion from the Championship with three games to spare on Friday.
Gujarat sink Kolkata with adaptable bowling in IPL
Gujarat Titans adapted to conditions to secure a five-wicket win over Kolkata Knight Riders on Friday, fast bowler Kagiso Rabada said, focusing on tight bowling instead of the explosive batting that has been the hallmark of the Indian Premier League.
Alcaraz pulls out of Madrid Open for second straight year
Carlos Alcaraz will miss the Madrid Open for the second consecutive year after withdrawing on Friday with a wrist injury, dealing another blow to the world number two's clay court preparations ahead of his French Open title defence.
Injured Djokovic to miss Madrid Open
Novak Djokovic is still working through the injury problems that forced him to miss recent tournaments in Miami and Monte Carlo and said on Friday that he will not feature at next week's Madrid Open, one of the last stops before the French Open.
Mumbai's IPL campaign fizzles amid Bumrah's barren run
Mumbai Indians head coach Mahela Jayawardene has defended Jasprit Bumrah after the struggling pace spearhead went a fifth Indian Premier League match without a wicket in Thursday's seven-wicket defeat by Punjab Kings.
Bus operations for public and private schools in the UAE will resume on Monday, April 20.
Dubai Police, in collaboration with the UAE Ministry of Interior, have arrested an Irish fugitive accused of involvement in an organised criminal group linked to international crimes in his home country.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has met with His Highness Sheikh Hamad bin Mohammed Al Sharqi, Supreme Council Member and Ruler of Fujairah, to discuss national priorities and the country’s continued development.
